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Pdk1 Gene

This protein can be phosphorylated by tyrosine kinases. Diseases associated with AKT1 include Proteus Syndrome and Cowden Syndrome 6.


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Among its related pathways are 14-3-3 and Regulation of BAD Activity and 4-1BB Pathway.

Pdk1 gene. The protein encoded by this gene is a member of the signal-regulatory-protein SIRP family and also belongs to the immunoglobulin superfamily. This gene encodes a member of the polycystin protein family. AKT1 AKT SerineThreonine Kinase 1 is a Protein Coding gene.

SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. It is also involved in cell-cellmatrix interactions and may. The encoded glycoprotein contains a large N-terminal extracellular region multiple transmembrane domains and a cytoplasmic C-tail.

Gene Ontology GO annotations related to this gene include identical protein binding and protein kinase activity. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis.


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